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SLO


DNA Research  


BeaCon has funded a lab research project in the amount of $10,300. The program will evaluate DNA of a small group of SLO affected Beardies and a small group of control Beardies (healthy 8 years old or over) without SLO.  The project is administered by AKC CHF and the principle investigator is Dr. Anita Oberbauer at UCDavis.   She has been collecting samples, medical histories, and pedigrees for this purpose for several years.  More participants are needed; click here  


Clinical Research


The role that environmental factors, heredity, and use of preventives for fleas, ticks, or heartworm might have on the development of SLO is not known.  BeaCon created a survey in 2008 to gather information.   A 2011 summary of findings is below.


More participants are needed in the clinical research; we ask you to consider donating your time and dog’s history for the cause.  Before starting the survey you should gather the dog’s vaccination record, health history, use of preventives (tick & flea) and registered names of sire and dam. Once you click the done button at the end of the survey, you cannot return.


Findings in 2011

For 84 dogs the age of onset was before 8 years in 89% and average age of 3.9 years. Diagnosis was by biopsy in 35 (12 claw, 16 nail, 7 skin); the rest were diagnosed by clinical response to treatment regimens for SLO.  About half had been vaccinated in the prior 6 months.  There were no unique preventive practices or preceding stressful events associated with development of SLO.


Clinical findings



          













Treatments included fatty acids (83%), tetracyclines (64%), niacinamide (52%), pain control (31%); among infrequent drugs were prednisone, vitamin C, trental, and immunosupppressives. There was a range in dosage, duration, and source and type of each drug class.  SLO was ongoing or recurring for all but 13 dogs.    

Family History.  Additional dogs from the open registry or breeder input are included in the families.  This aspect is incomplete because family information has not always been made available.  Families are named by a letter of the alphabet which has no relationship to kennel names.

The numbers of affected dogs and those with complete enough littermate history to allow calculation of the minimum affected litter rate are given in the next table.  The affected ratio varied from a low of 11% to a high of 50%.



              


                                                                                                                                                                                             

Clinical Sign

# dogs

percentage

pain

73

87%

nails fall off

67

80%

abnormal nail growth

64

76%

bleeding

63

75%

split nails

61

73%

persistent licking

55

66%

lameness

49

58%

infection

49

58%

Family

# SLO dogs

# dogs with complete littermate history

A

6

3

B

18

12

C

20

9

E

19

12

F

2

2

G

4

3

H

34

14

L

3

3

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